| Special Lecture <1> |
| Developmental immunotoxicity induced by dioxins |
Steven D. Holladay |
Anatomy and Toxicology,College of Veterinary Medicine, Virginia Polytechnic Institute |
| Special Lecture <2> |
| Induction of Allergic Diseases and Fc receptor |
T. Saito |
Department of molecular genetics, Graduate school of medicine,Chiba University |
| Workshop |
| Collaborative study to establish immunotoxicology evaluation procedures for pharmaceuticals |
Kazuichi Nakamura |
Immunotoxicology Working Group, Preclinical Evalution Subcommittee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association; Developmental Research Laboratories, Shionogi & Co., Ltd. |
| Collaborative study to establish immunotoxicology evaluation procedures for pharmaceuticals using promethazine hydrochloride |
T. Morita(1)，H. Irie(2)，T. Kimura(3)，M. Sakaguchi(4)，H. Doi(5)，H. Hattori(6)，D. Mukai(7) |
(1)Toyama Chemical Co.，(2)Welfide Co.，(3)Toa Eiyo Ltd.，(4)Fuji Biomedix Co.，(5)Takeda Chemical Industries，(6)Daiichi Pharmaceutical Co.，(7)Biosafety Research Center |
| Collaborative study to establish immunotoxicology evaluation procedures for pharmaceuticals using indomethacin |
Y. Kuninishi(1)，S. Hisada(2)，S. Ozawa(3)，K. Hoshino(4)，J. Nishimura(5) |
(1)Kyorin Pharmaceutical Co.，Ltd.，(2)Teikoku Hormone Mfg. Co., Ltd.，(3)Kissei Pharmaceutical Co., Ltd.，(4)Yamanouchi Pharmaceutical Co., Ltd.，(5)Kowa Company, Ltd. |
| Collaborative study to establish immunotoxicology evaluation procedures for pharmaceuticals using dl - propranolol hydrochloride |
N. Sato(1)，T. Narita(2)，K. Mochizuki(3)，T. Kimura(4)，K. Suwa(5)，H. Izumi(6)，M. Nagata(7) |
(1)Asahi Chemical Industry Co., Ltd.，(2)Ajinomoto Co., Inc.，(3)Kaken Pharmaceutical Co., Ltd.，(4)Sankyo Co., Ltd.，(5)Bozo Research Center Inc., (6)Shin Nippon Biomedical Laboratories Ltd.，(7)Shionogi & Co., Ltd. |
| Collaborative study to establish immunotoxicology evaluation procedures for pharmaceuticals using 5-fluorouracil |
K. Tanaka(1)，M. Kokubu(2)，M. Yano(3)，Y. Tagawa(4)，H. Kato(5) |
(1)Kyowa Hakko Kogyo Co., Ltd.，(2)Panapharm Laboratories Co., Ltd. ，(3)Environmental Biological Life Science Research Center Inc. (BILIS)，(4)Sanwa Kagaku Kenkyusho Co., Ltd.，(5)Sumitomo Chemical Co., Ltd. |
| Collaborative study to establish immunotoxicology evaluation procedures for pharmaceuticals using nortriptyline hydrochloride |
Y. Takahashi(1)，T. Aoki(2)，Y. Mera(3)，K. Yagi(4)，M. Chino(5)，H. Hattori(6) |
(1)Shin Nippon Biomedical Laboratories, Ltd.，(2)Eisai Co., Ltd.，(3)Zeria Pharmaceutical Co., Ltd.，(4)Taisho Pharmaceutical Co., Ltd.，(5)Ina Research Inc.，(6)Daiichi Pharmaceutical Co., Ltd. |
| Collaborative study to establish immunotoxicology evaluation procedures for pharmaceuticals using haloperidol |
A. Hisatomi(1)，M. Nagata(2)，H. Atai(3)，J. Kawahara(4)，N. Wada(5)，S. Hisada(6) |
(1)Fujisawa Pharmaceutical Co., Ltd.，(2)Shionogi & Co., Ltd.，(3)Mitsubishi Chemical Safety Institute Ltd.，(4)Kirin Brewery Co., Ltd.，(5)Aventis Pharma Ltd.，(6)Teikoku Hormone Mfg. Co., Ltd. |
| Collaborative study to establish immunotoxicology evaluation procedures for pharmaceuticals using diphenylhydantoin |
Tadashi Kosaka(1)，Kenji Naohara(2)，Shuji Ishizuka(3)，Yumiko Tsujimura(4)，D. Mukai(5) |
(1)Institute of environmental toxicology，(2)Dainippon Pharmaceutical Co.，(3)SSP Co.，(4)Pfizer Pharmaceutical Inc.，(5)Biosafety Research Center |
| Symposium |
| Immunotoxicity due to medicine and chemical substances in clinical cases - Dermatology filed - |
E. Tanabe |
Department of Dermatology, Sakura Hospital, Toho University School of Medicine |
| Immunotoxicity due to medicine and chemical substances - Respiroatory Diseases - |
Hiroshi Kimura |
Department of Chest Medicine, Chiba University School of Medicine |
| Liver dysfunction caused by various drugs |
O. Yokosuka |
Department of Medicine, Chiba University School of Medicine |
| Adverse effects of drugs on blood cells and hematopoiesis |
T. Iseki |
Division of Molecular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo |
| Drug induced nephropathies -Clinical cases- |
S. Ueda(1)，M. Ogawa(2)，Y. Makino(2)，S. Hasegawa(2) |
(1)Dept of Drug Information and Communication，Graduate School of Pharmaceutical Sciences, Chiba University, (2)The First Dept. of Internal Medicine, School of Medicine, Chiba University |
| General Presentation |
| Analysis of immunological biomarkers from toluene diisocyanate-sensitized miceI humoral immunity responses(productivity of antibodies) |
T. Shindo(1)，Y. Kanazawa(1)，M. Furuya(1)，K. Kojima(1)，R. Teshima(2)，H. Okunuki(2)，J. Sawada(2)，K. Takahashi(3)，M. Ohsawa(3)，T. Yoshida(4） |
(1)Hatano Research Institute, Food and Drug Safety Center，(2)Department of Biochemistry and Immunochemistry, National Institute of Health Sciences，(3)Faculty of Pharmaceutical Sciences, Teikyo University，(4)Asahikawa Medical College |
| Analysis of immunological biomarkers in toluene diisocyanate-sensitized mice.(2) Composition and function of T lymphocytes |
M. Ohsawa(1)，F. Otsuka(1)，T. Yoshida(2)，T. Kinoue(3)，T. Shindo(4)，Y. Kanazawa(4)，K. Kojima(4)，J. Sawada(5) |
(1)Faculty of Pharmaceutical Sciences, Teikyo University，(2)Asahikawa Medial College ，(3)School of Medicine, Tokai University，(4)Food and Drug Safety Center，(5)National Institute of Health |
| Application of the mouse popliteal lymph node assay to immunotoxicological evaluation of drugs |
T. Kimura(2)，T. Aida(2)，K. Nagami(1)，K. Watanabe(1)，K. Tanaka(1)，H. Irie(1)，M. Yokota(1)，A. Suda(1)，K. Nakamura(1) |
(1)Immunotoxicology Working Group, Preclinical Evaluation Subcommittee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association; (2)Sankyo Co., Ltd. |
| Lymphocyte subset analysis in popliteal lymph node assay (PLNA) |
T. Aida，K. Muramatsu，M. Ajioka，T. Kimura |
Medical Safety Research Laboratories, Sankyo Co., Ltd. |
| Flow cytometric analysis of bromodeoxyuridine incorporated cells in the murine local lymph node assay |
N. Tsutsui，S. Mochiduki，J. Soejima |
Toxicology Laboratory, Yokohama Research Center, Mitsubishi-Tokyo Pharmaceuticals, Inc. |
| Local lymph node assay with non-radioactive alternative endpoints |
Masahiro Yamashita(1)，Akiko Suda(2)，Mitsuyuki Tabei(1)，Hans-Werner Vohr(1)，Naohisa Tsutsui(1)，Ritsuyoshi Suzuki(1)，Katsuaki Kikuchi(1)，Kouki Mochizuki(1)，Kazuichi Nakamura(1) |
(1)Immunotoxicology Working Group, Preclinical Evaluation Subcommittee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association; (2)Taisho Pharmaceutical Co., LTD. |
| Evaluation of immune-disrupters' effects on fetal thymus proliferation and differentiation in fetal thymus organ culture system |
J. Soejima，I. Hosokawa，S. Mochiduki，N. Tsutsui |
Toxicology Laboratory, Yokohama Research Center, Mitsubishi-Tokyo Pharmaceuticals, Inc. |
| Reproductive immunotoxicity of the endocrine disruptors on rat |
N. Naukura，Y. Shinozaki，A. Hasegawa，T. Nakamura，S. Yano，K. Ueno |
Department of Molecular Pharmacology and Pharmacothrepeutics. Graduate School of Pharmaceutical Sciences, Chiba Univerisity |
| Immunotoxicological effects of endocrine disrupting chemicals on mouse lymphocytes blastformation and the involvement of the estrogen receptor |
F. Sakazaki，K. Ueda，F. Kurashima，D. Shiota，H. Ueno，K. Nakamuro |
Division of Environmental Health, Faculty of Pharmaceutical Sciences, Setsunan University |
| Apoptotic cell death induced by an asbestos, chrysotile B: Analysis using human lymphoid cell lines and trial to establish chrysotile B-resistant subline |
T. Otsuki(1)，H. Sakaguchi(1)，M. Uno(2)，Y. Matsuo(3)，A. Tomokuni(1)，F. Hyodoh(1)，Y. Isozaki(1)，A. Ueki(1) |
(1)Dept. Hyg., & (2)Radiat. Oncol., Kawasaki Med. Sch., Kurashiki, (3)Fujisaki Cell Center, Hayashibara Biochem. Lab., Okayama |
| Cell death suppression factors in tolerance manifestation of organotin-induced thymus atrophy |
H. Suzuki(1)，Y. Ohtani(1)，M. Murayama(1)，C. Ono(1)，C. Yamaguchi(1)，Y. Arakawa(1)，T. Takeuchi(2)，Y. Nakano(2)，H. Nakashima(3) |
(1)Dept. of Hygiene & Preventive Medicine, Faculty of Health Sciences, The University of Shizuoka，(2)Research Reactor Institute, Kyoto University，(3)Ohsaka Prefectural Institute of Public Health |
| Immunotoxicological effects of environmental chemicals I.-Fly ash extracts from municipal waste incinerator- |
Y. Kanazawa(1)，H. Yoshino(2)，T. Shindo(1)，M. Furuya(1)，R. Ohta(1)，K. Kojima(1) |
(1)Hatano Research Institute, Food and Drug Safety Center，(2)Division of Environmental Engineering, Kanagawa Environmental Research Center |
| Immunosuppressive effect of aristolochic acid Ⅰ,Ⅱin inbred mice |
H. Asai，N. Sato，S. M. Chen，T. Kawanabe，M. Manabe，S. Yamagata，M. Mochizuki，S. Ueda |
Drug Information and Communication, Faculty of Pharmaceutical Sciences, Chiba University |
| Does not the secretory IgA against Japanese Cedar Pollen be induced during Pollen Season in spring? |
S. Tsujita，K. Morimoto |
Dept. of Social and Environmental Medicine, Osaka University Graduate School of Medicine |
| Evaluation of allergenic components in buckwheat and its products. Antigenicity tests in guinea pigs and ELISA |
K. Kojima(1)，Y. Kanazawa(1)，T. Shindo(1)，Y. Iijima(2) |
(1)Hatano Research Institute, Food and Drug Safety Center，(2)Final Product Development Division, Sakuma Confectionery Co., Ltd. |
| Predisposition and preceding factors of "occupational allergy in doctors" in medical students |
K. Sato，Y. Kusaka |
Dept. of Environmental Health, School of Medicine, Fukui Medical University |
| Effect of TCDD on immune response in NC/Nga mice |
H. Fujimaki，K. Nohara |
National Institute for Environmental Studies |
| Protective effects of Ro 40-8757 on immunotoxicities induced by cyclophosphamide |
T. Inoue，I. Horii |
Dept. of Preclinical Science, Nippon Roche Research Center |
| Modulating effects of indomethacin and pentoxifylline on TNF production |
Mamoru Inoue，Kohki Mochizuki，Junichi Yoshida |
Safety Research Department, Central Research Laboratories, Kaken Pharmaceutical Co., Ltd. |
| Study on iodine allergy 1. Specificity of antigen recognition of anti-iodine antibody and generation of iodinated protein from inorganic and organic iodine containing chemicals |
H. Shionoya，Y. Sugihara，K. Okano，F. Sagami，K. Mikami，K. Katayama |
Eisai Tsukuba Research Laboratories, Eisai Co., Ltd. |
| Study on iodine allergy 2. Characteristics of adverse reactions to contrast media in relation to iodinated self protein antigen hypothesis and development of a skin diagnostic agent of iodine allergy devoid of sensitizing antigenicity |
Y. Sugihara，H. Shionoya，K. Okano，F. Sagami，T. Mikami，K. Katayama |
Eisai Tsukuba Research Laboratories, Eisai Co., Ltd. |
