| Special Invited Lecture |
| Chemical-and drug-induced autoimmunity and its mechanisms: what do T cells recognize in adverse immunec reactions to chemicals? |
E. Gleichmann, T. Pape, M. Wulferink, P. Griem |
Division of Immunology, Medical Institute of Environmental Hygiene at Heinrich Heine University |
| Special Lecture |
| Cytokines in diseases: new approaches to clinical use |
S. Asano |
Institute of Medical Science, University of Tokyo |
| Symposium |
| Problems on the drug-induced anaphylactic reactions |
M. Muranaka |
Yugawara Kosei-nenkin Hospital |
| Delayed drug allergy, -especially, action mechanism of drug allergens in allergic eruptions induced by Oxicam derivatives- |
Z. Ikezawa |
Urafune Hospital, Dept. of Dermatology, Yokohama City Uni. School of Medicine |
| Food allergy |
S. Kaminogawa |
Dept.of Applied Biological Chemistry, The University of Tokyo |
| Working environment and allergy: a lesson from study on hard metal disease |
Y. Kusaka |
Department of Environmental Health, School of medicine, Fukui Medical University |
| Workshop |
| International trend on immunotoxicity testing guidelines in experimental animals: Immunopathological examinations |
K. Mitsumori |
Division of Pathology, National Institute of Health Sciences |
| Current topics in functional immunotoxicity testing guidelines |
J. Sawada |
Division of Biochemistry and Immunochemistry, National Institute of Health Sciences |
| Practice and the point at issue of antigenicity study using guinea pigs |
E. Maki |
Preclinical Development Dept., Research & Development Division, Janssen-Kyowa, Co., Ltd./JPMA |
| Investigations of allergenicity test in mice |
K. Shinkai, T. Aida, N. Ishikawa, T. Kimura |
Laboratory Animal Science & Toxicology Laboratories, Sankyo Co., Ltd. |
| General Presentation |
| Differences in immune responses to low-molecular compounds in three guinea-pig strains |
T. Aida, N. Ishikawa, K. Shinkai |
Laboratory Animal Science & Toxicology Laboratories, Sankyo Co., Ltd. |
| Histopathological differences between Arthus and delayed-type hypersensitivity reactions to a low-molecular compound in guinea-pigs |
T. Kimura, T. Aida, I. Igarashi, N. Ishikawa, K. Shinkai |
Laboratory Animal Science & Toxicology Laboratories, Sankyo Co., Ltd. |
| Investigation of antigeninity study methods in guinea pigs |
K. Nagami, Y. Kawashima, H. Kuno, H. Matsumoto |
Development Research Laboratories, Banyu Pharmaceutical Co., Ltd. |
| A prediction of chemical-induced immunogenicity using popliteal lymph node assay |
Y. Kouchi, Y. Maeda, A. Ohuchida |
Drug Safety Research Laboratory, Taiho Pharmaceutical Co., Ltd. |
| An attempt of development of a murine model for TDI asthma through an intratracheal administration |
K. Ebino(1), J.A.Kramarik(2), M.H. Karol(2) |
(1)Dept. of Toxicology, Institute of Environmental Toxicology, (2)Dept. of Environmental and Occupational Health, University of Pittsburgh |
| Investigation of antigenicity screening methods with an in-vitro system |
T. Inoue, K. Shimura, I. Horii |
Dept. of Toxicology and Pathology, Nippon Roche Research Center |
| Development of an ELISA for measurement of specific antibodies to a humanized monoclonal antibody |
J. Soejima, S. Mochizuki, N. Tsutsui, H. Inoue |
Toxicology Laboratory, Yokohama Research Center, Mitsubishi Chemical Corporation |
| Effects of carrot juice on the production of IgE and IgG antibody in mice |
H. Akiyama(1), K. Hoshino(1), R. Teshima(2), Y. Goda(1), J. Sawada(2), M. Toyoda(1) |
(1)Div. of Foods , (2)Div. of Biocheminstry and Immunochemistry, National Institute of Health Sciences |
| Effencts of some antioxidants and vanadate on TNF- α production of RBL-2H3 cells |
R. Teshima, J. Onose, J. Sawada |
Div. of Biochemistry and Immunochemistry, National Institute of Health Sciences |
| Ozone exposure inhibits contact hypersensitivity responses in mice |
H. Ushio, H. Fujimaki |
Environmental Health Science Div. National Institute for Environmental Health Studies |
| The rat strain differences in the immunotoxicological parameters |
Y. Kanazawa(1),T. Adachi(2),M. Furuya(2),K. Kojima(1,2) |
(1)Lab. of Immunotoxicol., (2)Bio. Chem., Hatano Res. Inst., Food and Drug Safety Center |
| Effects of antigen stimulation on the splenic lymphocyte subsets of cyclophosphamide-treated rats |
M. Nagata, M. Hino, S. Kimura, A. Watanabe, M. Takeuchi, K. Nakamura |
Developmental Research Laboratories, Shionogi & Co., Ltd. |
| Evaluation of immunotoxicity tests using dexamethasone and cyclosporin A-III |
M. Inoue, R. Nagatahira, K. Mochizuki, Y. Ito, J. Yoshida, K. Saitoh |
Safety Research Laboratories Kaken Pharmaceutical Co., Ltd. |
| Effects of Pyridine-triphenylborane on the tissues of immune system in rats |
T. Tamura, K. Toyoda, T. Shoda, C. Uneyama, K. Mitsumori, K. Takada, M. Takahashi |
Division of Pathology, National Institute of Health Sciences |
| Role of nitric oxide in cocain-induced immunosuppression |
K. Aoki, R. Kuwabara, T. Yoshida |
Dept. of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University |
| Inhibitory effects of Chinese medicine extracts on leukocyte apoptosis and immunotoxicity induced by doxorubicin |
N. Toma, S. Toyoshima |
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hoshi University |
| Restraint stress effect and its modification by high vitamin-E intake on immune system in young and aged mice |
J. Kanno(1,2),A. Wakikawa(2),M. Utsuyama(2),K. Hirokawa(2) |
(1)Division of Cellular and Molecular Toxicology, National Institute of Health Sciences,(2)Department of Pathology and Immunology, School of Medicine, Tokyo Medical and Dental University |
| Immunomodulating effects of electromagnetic field exposure |
T. Yoshida(1),T. Hagino(1),F. Kayama(2) |
(1)Dept. of Environmental Health, Tokai University, School of Medicine, (2)Dept. of Hygiene, Jichi Medical College |
| Preventive medical study on stress reactions after the Great Hanshin-Awaji Earthquake. Part 13. The association of lifestyle and PTSD-like symptoms with natural killer cell activity |
C. Sakurai, S. Maruyama, S. Fukuda, K. Morimoto |
Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine |
| Ovariectomy induces enhanced production of proinflammatory cytokines from liver, kidney and bone marrow cells |
F. Kayama, K. Nakatsuka |
Department of Environmental Health, Jichi Medical School |
| Augmentation of autoimmune arthritis by diesel exhaust particles |
S. Yoshino(1),M. Ohsawa(2),M. Sagai(3) |
(1)Dept.of Microbiology, Saga Medical School, (2)Dept. of Environmental Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, (3)Research Team for Health Effects of Air Polutions, Nat. Inst. for Environmental Studies, |
| Dysregulation of Fas/Fas ligand system in apoptosis mechanisms for acquisition of autoimmunity in cases with silicosis |
T. Otsuki, A. Tomokuni, T. Aikoh,A. Ueki |
Dept. Hygiene, Kawasaki Med. Sch. |
