| Special Lecture@ |
| Immunotoxicological evaluation of chemicals and therapeutics: an update perspective |
Michael I. Luster |
Environmental Immunology & Neurobiology Section National Institute of Environmental Health Sciences/NIH, NC |
| Workshop |
| Collaborative immunotoxicity study by seven-day oral administration of cyclophosphamide -hematological, blood chemical and pathological investigation - |
Y. Nomoto(1),K. Taguchi(2),Y. Sugihara(3),Y. Amano(4),K. Nakamura(5),Y. Kouchi(6),H. Nakamura(7),T. Masuda(8),S. Kawano(9),S. Inoue(10),K. Hayakawa(11),N. Tsutsui(12) |
(1)Kyorin Pharmaceutical, (2)Marion Merrell Dow, (3)Eisai, (4)Kowa, (5)Shionogi, (6)Taiho Pharmaceutical, (7)Takeda Chemical Industries, (8)Lederle (Japan), (9)Bristol-Myers Squibb, (10)Hoechst Japan, (11)Mitsui Pharmaceutical, (12)Mitsubishi Pharmaceutic |
| Collaborative immunotoxicological study by seven-day oral administration of cyclophosphamide - cellularity, flow cytometric analysis, mitogenic stimulation assay - |
H. Nakamura(1),S. Inoue(2),Y. Sugihara(3), T. Masuda(4),Y. Kouchi(5),K. Nakamura(6) |
(1)Takeda Chemical Industries, (2)Hoechst Japan, (3)Eisai, (4)Lederle (Japan),(5)Taiho Pharmaceutical, (6)Shionogi |
| Collaborative immunotoxicological study by seven-day oral administration of cyclophosphamide - evaluation of humoral immune response by plaque-forming cell assay and enzyme-linked immunosorbent assay- |
K. Nakamura(1),S. Kawano(2),S. Inoue(3),Y. Sugihara(4),T. Masuda(5),Y. Kouchi(6),M. Hayakawa(7) |
(1)Shionogi, (2)Bristol-Myers Squibb, (3)Hoechst Japan, (4)Eisai, (5)Lederle (Japan), (6)Taiho Pharmaceutical,(7)Mitsui Parmaceutical |
| Collaborative immunotoxicity study by seven-day oral administration of cyclophosphamide - natural killer activity, macrophage phagocytosis, colony-forming unit granulocyte/macrophage - |
Y. Kouchi(1),M. Hayakawa(2),Y. Sugihara(3),N. Tsutsui(4) |
(1)Taiho Pharmaceutical, (2)Mitsui, (3)Eisai, (4)Mitsubisi Chemical |
| Mini-symposium |
| Assessment of lymphocyte subpopulations in workers exposed to hazardous substances |
T. Tanigawa,S. Araki,A. Nakata |
Department of Public Health, Faculty of Medicine, University of Tokyo |
| Immunotoxicity of low dose formaldehyde exposure |
T. Yoshida |
Department of Environmental Health, Tokai University School of Medicine |
| Role of proinflammatory cytokines in cadmium-induced hepatic and renal toxicity |
F. Kayama(1),M. I. Luster(2) |
(1)Dept. of Environ Health, UOEH, (2)NIH/NIEHS |
| general Presentation |
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| Study on the method for predicting drug-allergy |
H. Shionoya,Y. Nonogaki,F. Sagami |
Dept. of Drug Safety Research, Eisai Co. Ltd. |
| Antigenicity of metabolic intermediates in aminopyrine allergy |
H. Shigematsu(1),Y. Hisanari(1),A. Toda(1),R. Eyanagi(2) |
(1)Dept. of Hygienic Chemistry, Daiichi College of Pharmaceutical Sciences, (2)Daiichi University-College of Technology |
| Pseudoallergy system using rat basophilic leukemia cell: phorbol ester potentiated a microsomal Ca2+ ATPase inhibitor to release histamine |
S. Kitajima(1),J. Momma(1),M. Tsuda(1),Y. Kurokawa(1),R. Teshima(2),J. Sawada(2) |
(1)Div. of Toxicology(2) Div. of Biochemistry and Immunochemistry, National Institute of Health Sciences |
| Determination of the optimum conditions in the enzyme-linked immunosorbent assay of antibody to sheep red blood cells |
M. Nagata,K. Nakamura |
Developmental Research Laboratories Shionogi & Co., Ltd. |
| Comparison of ELISA and plaque forming cell assays for measuring anti SRBC antibodies |
M. Miyamoto,H. Hattori,F. Yamaguchi,H. Ohno,M. Nomura |
Daiichi Parmaceutical Co., Ltd., Developmental Research Laboratories, Drug Safety Research Center |
| Improvement of histological examinations for the detection of immunotoxicity using biological parameters of cell proliferation and cell death |
K. Toyoda,T. Shoda,C. Uneyama,K. Takada,M. Takahashi |
Division of Pathology, National Institute of Health Sciences |
| Histopathological study on lymphoid tissue atrophy in rats treated with piperonyl butoxide |
K. Takegawa,H. Onodera,K. Mitsumori,T. Shimo,K. Yasuhara,M. Takahashi |
Division of Pathology, National Institute of Health Sciences |
| Immunotoxicological evaluation of dexamethasone in mice infected with Plasmodium chabaudi |
N. Tsutsui(1)(2),T. Kamiyama(1) |
(1)NIH of Japan, (2)Mitsubishi Chemical Corporation |
| Influence of HMG-CoA reductase inhibitors on plaque-forming cell (PFC) response in mice |
T. Kimura(1),K. Shinkai(1),H. Masuda(1),T. Komai(2),K. Nomoto(3) |
(1)Laboratory Animal Science and Toxicology Laboratories,(2)Pharmacology and Molecular Biology Research Laboratories, Sankyo Co., Ltd., (3)Medical Institute of Bioregulation, Kyushu University |
| Effects of quinolone antibacterial agents on humoral immune response in mice |
H. Hattori,M. Miyamoto,F. Yamaguchi,H. Ohno,M. Nomura |
Drug Safety Research Center, Developmental Research Laboratories, Daiichi Pharmaceutical Co., Ltd. |
| Effects of cytotoxic agents on peripheral lymphocyte and neutrophil nuclei |
K. Nagami,Y. Kawashima,T. Akima,K. Motegi,Y. Ban,K. Samura,H. Matsumoto |
Development Research Laboratories, Banyu Pharmaceutical Co., Ltd. |
| Comparison of in vitro colony formation of bone marrow cells between C57BL/6 mice and SD rats |
K. Matsumura,A. Ozaki |
Tokushima Research Institute, Otsuka Pharmaceutical Company |
| Toxic effects of 5-fluorouracil to the hematopoietic progenitor cells in mouse bone marrow |
Y. Maeda,Y. Kouchi,A. Ohuchida |
Drug Safety Research Laboratory, Taiho Pharmaceutical Co., Ltd. |
| Evaluation of in vitro toxicity of 32 MEIC compounds on human natural killer cell function |
Y. Kobayashi |
Lab.of Molecular Immunology, Faculty of Science, Toho University |
| Immunodeficiency by organotin-induced thymus atrophy and its tolerance manifestation |
J. Murata(1),Y. Arakawa(1),H. Nakashima(2) |
(1)Dept. of Hygiene and Preventive Medicine, Faculty of Healty Sciences, University of Shizuoka, (2) Osaka Prefectural Institute of Public Health |
| Changes of cell functions in murine macrophages and T cells by lead compounds |
K. Takagi,M. Kanematsu,T. Kawabe,Y. Suketa |
Dept of Environmental Biochemistry, School of Pharmaceutical Science, University of Shizuoka |
| Protective activity on experimental hepatitides and suppression of cytokine production by bisbenzylisoquinoline alkaloids |
F. Takano,K. Konno,S. Fushiya,Y. Kondo,Y. Yamazoe,H. Hojo |
Faculty of Pharmaceutical Sciences, Tohoku University |
| Tolerance to transpulmonary neutrophil infiltration and some problems in evaluation of pulmonary toxicity |
S. Hirano |
Regional Environ. Div., Natl. Inst. Environ. Studies |
