The 16th Annual Meeting of JSIT
2009.8.27-28. Asahikawa City Cultural hall
President: Takahiko Yoshida, Department of Health Science, Asahikawa Medical College, Asahikawa, Japan
Special Lecture I
Does immunomodulation early in life increase disease risk in children and beyond? Germolec Dori R (1),Dietert Rodney R (2) (1) National Toxicology Program, National Institute of Environmental Health Sciences
(2) Department of Microbiology and Immunology, Cornell University
Special Lecture II
Role of Asahiyama Zoo Masao Kosuge Director Emeritus of Asahikawa Asahiyama Zoo
Symposium
Children and Immunity Organizer
Fujio Kayama Jichi Medical University
Kazuichi Nakamura Shionogi & Co., Ltd.
Breakdown of mucosal immunity in the gut and allergic sensitization by dioxin Sho Ishikawa Dept of Molecular Preventive Medicine, The University of Tokyo, Tokyo, Japan
Health examination system to prevent fetal exposure of persistent organic pollutants (POPs) and atopic dermatitis in infants. Chisato Mori Center of Preventive Medical Science, Department of Bioenvironmental Medicine, Graduate School Medicine, Center for Environment, Health and Field Sciences, Chiba University
Prenatal exposure to cigarette smoke increases tumor susceptibility of juvenile mice via changes in anti-tumor immune mechanisms Zelikoff Judith T (1),Ng Sheung P (1),Yoshida Kotaro (1),Silverstone Allen E (.2),Lai Zhi-Wei (2) 1) New York University School of Medicine, Nelson Institute of Environmental Medicine
2) SUNY Upstate Medical University, Department of Microbiology & Immunology
Workshop
Standardization of an immunotoxicity test: T cell-dependent antibody response to keyhole limpet hemocyanin Organizer
Naohisa Tsutsui Mitsubishi Tanabe Pharma Co.
Shigeru Hisada Aska Pharmaceutical Co., Ltd.
Background for a discussion on standarized protocols of KLH-TDAR Naohisa Tsutsui Safety Research Laboratory, Research Division, Mitsubishi Tanabe Pharma, Chiba, Japan
Case 1: Rat strain comparison of T cell dependent antibody response using keyhole limpet hemocyanin as an antigen Ryota Kawai,Shiho Ito,Hiroyuki HattoriI,Tetsuo Aida,Tadashi Furukawa,Atsushi Sanbuissho Medicinal Safety Research Laboratories, DAIICHI SANKYO CO., LTD.
Case 2: Protocol for Rat KLH-TDAR in Takeda Pharmaceutical Company Limited Kanako Mori,Takako Iwachido,Masami Aoki,Hideki Yamasaki,Kenji Takami,Hirofumi Nagai Development Research Center, Pharmaceutical Division, Takeda Pharmaceutical Company Limited
Case 3:TDAR method using the commercial anti KLH-ELISA kit -Comparison with SRBC method- Horoyuki Komatsu SUGI Institute of Biological Science
Case 4: Case study of both anti-KLH IgM and IgG antibody measurement in TDAR testing Hideki Harada,Makoto Tsunimi,Hideki Tokudome,Takayuki Okamura,Yasuyuki Oonishi,Hideaki Hiratsuka Kashima Laboratory, Toxicological Science Division, Medi-Chem Business Segment, Mitsubishi Chemical Medience Corporation
Oral Presentations
Assessment of the influence of possible endocrine disruptors on the development of non-pathogenic-bacterial induced infectious diseases Noriko Mizutani(1), Masashi Muroi(1,2), Arisa Igarashi(1), Shinji Kanno(1), Yoichi Kamata(1), Yoshiko Konishi(1), Ken-ichi Tanamot(1,2) (1) Division of Microbiology, National Institute of Health Sciences, Tokyo, Japan, (2) Faculty of Pharmacy, Department of Pharmaceutical Sciences, Musashino University, Tokyo, Japan
Estrogen receptors in rainbow trout immune organs and cells Nakayama Ayako (1),Koellner Bernd (2),Eppler Elisabeth (3),Segner Helmut (1) (1) Centre for Fish and Wildlife Health, University of Bern, (2) Friedrich-Loeffler-Institute, (3) Research Group Neuro-Endocrine-Immune Interactions, University of Zurich
Effects of exposure to phthalates on atopic dermatitis-like skin lesions in NC/Nga mice Rie Yanagisawa,Hirohisa Takano,Eiko Koike,Ken-ichiro Inoue Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
Allergic reaction induced by dermal and/or respiratory exposure to several types of pesticides Tomoki Fukuyama, Yukari Tajima, Koichi Hayashi, Hideo Ueda, Yasufumi Shutoh,Takanori Harada,Tadashi Kosaka The Institute f Environmental Toxicology, Toxicology Division, Ibaraki, Japan
Suppression of airway responsiveness and eosinophilic infiltration in asthmatic mice by propolis Ryoji Hirota(1), Masamitsu Eitoku(1), Ken-ichi Yagyu(2), Hiroyuki Tanaka(3), Naoki Inagaki(3), Hiroichi Nagai(3), Hiroyuki Nakamura(4), Narufumi Suganuma(1) (1)Department of Environmental Medicine, Kochi Medical School Kohasu, Kochi, Japan, (2)The Science Research Center, Kochi University, (3 Bioactive Molecules, Gifu Pharmaceutical University, (4)Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Science.
Effect of ziram, a carbamate pesticide, on human NK activity Qing Li,Maiko Kobayashi,Tomoyuki Kawada Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
Development of a novel allergy test using a cultured mast cell line Nakamura Ryosuke,Yoshimi Uchida,Masakazu Higuchi,Reiko Teshima Div. Novel Foods Immunochem., Natl. Instit. Health Sci., Tokyo, Japan
A new In Vitro assay system for assessment of food allergenicity Terumi Katori(1), tomoko Shindo(1), Yukiko Kanazawa(1), Motoyasu Ohsawa(1), Kohichi Kojima(1), reiko Teshima(2) (1) Hatano Research Institute, Food and Drug Safety Center, Hadano, Japan,(2) National Institute of Health Sciences, Tokyo, Japan
Potential use of human erythropoietin transgenic mouse model as a tool for immunogenicity assessment Akifumi Shioda(1), Ryousuke Watanabe(2), Tomoaki Inoue(1), Masayuki Mishima(1) (1) Safety Assessment Dept., Fuji Gotemba Res. Labs., Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, (2)Pharmaceutical Res. Dept. 2, Kamakura Res. Labs., Chugai Pharmaceutical Co., Ltd., Kamakura, Japan
Effect of prenatal and postnatal exposure to low-level toluene on immune development in infant mice Shoji Yamamoto(1), Win-Shwe Tin-Tin(1), Naoki Kunugita(2), Yasuhiro Yoshida(3), Keiichi Arashidani(3), Hidekazu Fujimaki(1) (1) Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Japan, (2)Depertment of Environmental Health, National Institute of Public Health, Wako, Japan, (3)University of Occupational and Environmental Health, Kitakyushu, Japan
The effect of DPH and MXC on the immune response to SRBC-antigen in infant and adult female rats Koichi Hayashi,Tomoki Fukuyama,Yukari Tajima,Yukiko Kashimoto,Hideo Ueda,Yasufumi Shutoh,Takanori Harada,Tadashi Kosaka Institute of Environmental Toxicology, Ibaraki Japan
Effect of arsenite on lipopolysaccharide-induced activation of mouse macrophages Seiichiro Himeno,Koichiro Matsuda,Hiromasa Tsuyama,Hitomi Fujishiro Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
Benzo[a]pyrene-induced activation of murine immune cells Eiko Koike,Ken-Ichiro Inoue,Rie Yanagisawa,Hirohisa Takano Environmental Health Sciences Division, National Institute for Environmental Studies,Tsukuba, Japan
Effects of inflammation-related gene polymorphisms and atomic-bomb radiation exposure on risks of stomach and liver cancers Tomonori Hayashi(1), Waka Ohishi(1), Kazue Imai(1), Kengo Yoshida(1), Ikue Hayashi(2), Saeko Fujiwara(1), Yoichiro Kusunoki(1), Kei Nakachi(1) (1) Radiation Effects Research Foundation, Hiroshima, Japan, (2) Central Research Facility, Hiroshima University Faculty of Dentistry, Hiroshima, Japan
Associations between HLA alleles and Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients (Second report) Yoshiro Saito(1,2), Nahoko Kaniwa(1,2), Masahiro Tohkin(1,2), Kouichi Kurose(1,2), Jun-ichi Sawada(1), Kayoko Matsunaga(2), Yukitoshi Takahashi(2), Hirokazu Furuya(2), Masaaki Muramatsu(2), Chie Sotozono(2), Shigeru Kinoshita(2), Michiko Aihara(2), Zenro Ikezawa(2), Ryuichi Hasegawa(1,2) (1) National Institute of Health Sciences,(2) JSAR Research Group
Systematic evaluation between particle characteristics of silica and inflammatory responses Yasuo Yoshioka(1,2), Tomohiro Morishige(2), Hiroshi Inakura(2), Aya Tanabe(2), Yasuo Tsutsumi(1,3,4), Shin-ichi Tsunoda(4), Yuichi Kawai(5), Tadanori Mayumi(5), Yohei Mukai(2), ,Naoki Okada(2), Shinsaku Nakagawa(1,2) (1) The Center for Advanced Medical Engineering and Informatics, Osaka University, Osaka, Japan, (2) Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan, (3) Department of Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan, (4) Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation Osaka, Japan, (5) Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Kobe, Japan.
Enhancement of suppression function of MT-2 cells on T cell proliferation by long-term and low-level exposure to asbestos Megumi Maeda(1), Ying Chen(1), Hiroaki Hayashi(1), Naoko Kumagai(1), Yoshie Miura(2), Yasumitsu Nishimura(1), Takemi Otsuki(1) (1) Department of Hygiene, Kawasaki Medical School, Kurashiki, Okayama,Japan, (2) Department of Molecular Genetics, Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
Involvement of cytokines in suppressed induction of CTL upon exposure to asbestos Naoko Kumagai,Yasumitsu Nishimura,Megumi Maeda,Hiroaki Hayashi,Takemi Otsuki Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan
Analysis for suppressed expression of NKp46 on NK cells exposed to asbestos, possible predictive molecular marker for anti-tumor immune function Yasumitsu Nishimura(1), Naoko Kumagai(1), Megumi Maeda(1), Hiroaki Hayashi(1), Takumi Kishimoto(2), Takemi Otsuki(1) (1) Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan, (2) Okayama Rosai Hospital, Okayama, Japan
Development of an allergenicity assay for genetically modified animal foods Nakamura Rika(1), Ryosuke Nakamura(1), Hiroyuki Horiuchi(2), Reiko Teshima(1) (1) Division of Novel Foods and Immunochemistry, National Institute of Health Sciences, Tokyo, Japan, (2) Graduate School of Biosphere Science, Hiroshima University
Murine Food Allergy Model with Oral Sensitization and Oral Challenge (7) Tomoko Shindo(1), Terumi Katori(1), Yukiko Kanazawa(1), Motoyasu Ohsawa(1) Kohichi Kojima(1), reiko teshima(2) (1) Hatano Research Institute, Food and Drug Safety Center, Hadano, Japan, (2) National Institute of Health Sciences, Tokyo, Japan
Parabens enhance mouse contact hypersensitivity Fumitoshi Sakazaki,Naoe Chinen,Mari Matsuo,Hirofumi Ogino,Megumi Shiroshita,Hitoshi Ueno,Katsuhiko Nakamuro Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan
Poster Presentations
T-cell Dependent Antibody Response in Spontaneously Hypertensive rat. - Effects of Immunosuppressive Drugs on Primaly Antibody Response - Akihiko Hisatomi,Kiyoshi Kushima,Kenji Hoshino,Michio Fujiwara Drug Safety Research Labs. Astellas Pharma Inc.
Immunotoxicity evaluation in beagle dogs, including T-cell dependent antibody response Ryota Kawai,○Shiho Ito,Hiroyuki Hattori,Tetsuo Aida,Hidetoshi Ooshima,Satomi Komatsu,Toshihiko Makino,Kumi Honda,Tadashi Furukawa,Atsushi Sanbuissho Medicinal Safety Research Laboratories, DAIICHI SANKYO CO., LTD., Shizuoka, Japan
Relationship between blood lymphocyte decrease induced by administration stress and CXCR4-mediated T cell migration in cynomolgus monkeys Takayuki Okamura,Hideki Tokudome,Makoto Tsunemi,Kiyohisa Fukasawa,Hideki Harada,Yasuyuki Ohnishi,Hideaki Hiratsuka Toxicological Science Division, Mitsubishi Chemical Medience Corporation, Kashima, Japan
Effects of toluene exposure on developmental immunotoxicity in infant mice brain Tin-Tin Win-Shwe(1), Naoki Kunugita(2), Shoji Yamamoto(1), Keiichi Arashidani(3), Hidekazu Fujimaki(1) (1)National Institute for Environmental Studies, (2)National Institute of Public Health, (3)University of Occupational and Environmental Health, Kitakyushu, Japan
Effect of Oenothein B on cultured human dendritic cells Hideki Matsuoka(1), Morio Yoshimura(2), Hiroshi Akiyama(1), Kozue Sakata(1), Yoshiaki Amakura(2), Takashi Yoshida(2), Reiko Teshima(1) (1) Division of Novel Foods and Immunochemistry, National Institute of Health Sciences, Tokyo, Japan, (2) College of Pharmaceutical Sciences, Matsuyama University, Ehime, Japan
Effects of exposure to low-dose arsenite on degranulation of mast cell ( 2 ) Yuri Shimizu,Seiichiro Himeno Tokushima Bunri University,Faculty of Pharmaceutical Sciences,Laboratory of Molecular Nutrition and Toxicoloby,Tokushima,Japan
Effects of acute inflammation of indigenous bacteria on lung asbestosis. Kyoko Hiyoshi(1), shoji Yamamoto(2), Ken-ichiro Inoue(3), Takamichi Ichinose(4) (1) School of Nursing, University of Shizuoka, Shizuoka, Japan, (2) Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Japan, (3) Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan, (4) Department of Health Sciences, Oita University of Nursing and Health Sciences, Oita, Japan
Immunological effects of CD4+CD25+T cells exposed to silica. Hiroaki Hayashi(1), Megumi Maeda(1), Naoko Kumagai(1), Yasumitsu Nishimura(1), Masayasu Kusaka(2), Kouzou Uragami(3), Takemi Otsuki(1) (1) Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan, (2) Kusaka Hospital, (3) Uragami Iin
Cytokine alteration and speculated immunological pathology in silicosis and asbestos-related diseases Takemi Otsuki(1), Megumi Maeda(1), Shuko Murakami(1), Naoko Kumagai(1), Hiroaki Hayashi(1), Yoshie Miura(2), Yasumitsu Nishimura(1), Masayasu Kusaka(3), Takumi Kishimoto(4) (1) Dept. Hygiene, Kawasaki Med. Sch., Kurashiki, Japan, (2) Dept. Mol. Genet., Med. Inst. Bioregulation, Kyushu Univ., Fukuoka, Japan, (3) Kusaka Hosp., Bizen, Japan, (4)Okayama Rosai Hops., Okayama, Japan
Cytotoxicity study of high-alumina low-silica stone wool by cell magnetometric evaluation Yuichiro Kudo,Sachiyo Mogi,Yumi Komatsu,Etsuko Ohta,Michiyo Koyama,Yumiko Sugiura,Masashi Tsunoda,Yoshiharu Aizawa Department of Preventive Medicine and Public health, Kitasato University School of Medicine
Effectiveness of self-check software on the website to prevent Sick Building Syndrome Hiroko Nakaoka(1,2), Emiko Todaka(1,2), Masamichi Hanazato(2,3), Chisato Mori(1,2,4) (1) Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan, (2) Center for Environment, Health and Field Sciences, Chiba University, Kashiwa, Chiba, Japan, (3) Department of Architecture, Graduate School of Engineering, Chiba University, Chiba, Japan, (4) Center for Preventive Medical Science, Chiba University, Chiba, Japan
The Current Situation and Treatment of Sick-Building Syndrome Caused by Volatile Organic Compounds Including Flame Retardants Emiko Todaka(1,2), Hiroko Nakaoka(1,2), Masamichi Hanazato(1,3), Chisato Mori(1,2,4) (1) Center for Environment, Health and Field Sciences, Chiba University, Kashiwa, Chiba, Japan, (2) Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan, (3) Department of Architecture, Graduate School of Engineering, Chiba University, Chiba, Japan, (4) Center for Preventive Medical Science, Chiba University, Chiba, Japan
A Suggestion of Town Planning to Prevent Adverse Health Effect by Environmental Chemicals Masamichi Hanazato(1,2), Hiroko Nakaoka(1,3), Emiko Todaka(1,3), Chisato Mori(1,2,4) (1) Center for Environment, Health and Field Sciences, Chiba University, Kashiwa, Chiba, Japan, (2) Department of Architecture, Graduate School of Engineering, Chiba University, Chiba, Japan, (3) Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan, (4) Center for Preventive Medical Science, Chiba University, Chiba, Japan
Luncheon Seminar <1>
Pharmacodynamic endpoints in the assessment of immunotoxicity forbiopharmaceutical development Gregory Bannish Department of Cell Biology & Immunology, Huntingdon Life Sciences Inc. (US)
Luncheon Seminar <2>
Pre-clinical Vaccine Development and Immune Monitoring Lawrence Jacob Charles River Laboratories