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The 14th Annual Meeting of JSIT |
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September 20-21, 2007, Kobe, Japan
President: Shin Yoshino (Kobe Pharmaceutical University)
| Special Lecture |
| Prediction of Hepatotoxicity using Toxicogenomics Project Database （TG-GATEs） |
Tetsuro Urushidani |
Department of Pathophysiology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe, Kyoto, Japan / Toxicogenomics/Informatics Project, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan |
| Invited Lecture 1 |
| Mast cells and KIT receptor tyrosine kinas |
Yunihiko Kitamura |
Developmental Research Laboratories, Shionogi Co. Ltd. |
| Invited Lecture 2 |
| Drug Induced Allergy |
Edith Sim |
Department of Pharmacology, University of Oxford,UK. |
| Symposium |
| Developmental Immunotoxicology |
Organizer |
Kazuichi Nakamura |
Shionogi Co. Ltd. |
| Kenneth L. Hastings |
FDA, USA |
| Molecular mechanism of specific immune system on maternal decidua |
Orie Nakamura |
Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan |
| Ontogeny and Post-Natal development of the rodent immune system |
Hayssam Khali |
Charles River Laboratories, Preclinical Services, Immunology (CANADA) |
| Immune system development in the primate |
Gerhard F. Weinbauer |
Werner Frings, Antje Fuchs, Eberhard Buse, Covance Laboratories GmbH |
| Developmental Immunotoxicity and Critical Windows of Exposure for Children's Health |
Rodney R. Dietert |
Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14883 and Director of Developmental Immunotoxicology, Burleson Research Technologies, Morrisville, NC |
| Regulatory Concerns for Developmental Immunotoxicology |
Kenneth L. Hastings |
FDA, USA |
| Workshop |
| Issues and Measures of Immunotoxicological Assessment |
Organizer |
Jun-ichi Sawada |
National Institute of Health Sciences |
| Eiji Maki |
BiosafetyResearchCenter, Foods, Drugs and Pesticides |
| Pathological considerations of immune system in non-human primates |
Hiroshi Maeda |
TokyoPathologyCenter, Shin Nippon Biomedical Laboratories, Ltd., Tokyo, Japan |
| Introduction and notes of immune function tests in monkeys |
Takayuki Okamura, Hideki Harada, Yasuyuki Ohnishi |
Safety Assessment Division I, Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd., Kashima, Japan |
| Preclinical Safety Assessment Issues in the Development Process of TGN1412 |
Kiyoshi Kobayashi |
Amgen K.K., Tokyo, Japan |
| Points to consider for safety evaluation of monoclonal antibody pharmaceuticals |
Tomoaki Inoue |
Safety Assessment Dept., Fuji Gotemba Research Labs., Chugai Pharmaceutical Co., Ltd., Japan |
| General Session (Oral Presentation) |
| Evaluation of immunostimulation by drugs using mouse popliteal lymph node response to reporter antigens |
Shiho Ito (1), Tetsuo Aida (1), Gutting Bradford Wesley (2), Ryota Kawai (1), Tadashi Furukawa (1) |
(1) Medicinal Safety Research Laboratories, Daiichi Sankyo Co. Ltd., Shizuoka, Japan, (2) Naval Surface Warfare Center, Dahlgren, VA, USA |
| The role of T lymphocytes in toluene-induced increased memory-related gene expressions in the hippocampus of mice |
Tin Tin Win Shwe, Shoji Yamamoto, Hidekazu Fujimaki |
ResearchCenter for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Japan |
| Lifestyle affects human NKT cells |
Qing Li (1), Kanehisa Morimoto (2), Tomoyuki Kawada (1) |
(1) Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan, (2) Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Osaka, Japan |
| The effects of fluoride on cytokine productions of splenocytes in the rats after administration for two month in the drinking water |
Masashi Tsunoda (1), Sachiko Kimura (1,2), Masayoshi Tsuji (1,3), Ying Zhang (1), Chiemi Sugaya (1), Yoko Inoue (1),Yuichiro Kudo (1), Toshihiko Satoh (1), Hiroshi Katagiri (4), Kazuyoshi Itai (5), Yoshiko Sugita-Konishi (6), Yoshiharu Aizawa (1) |
(1) Department of Preventivve Medicine and Public Health, Kitasato University School of Medicine, Sagamihara, Japan, (2) Kanagawa Prefecture Ken-o Livestock Hygiene Station, Atsugi, Japan, (3) Mejiro University College, Tokyo, Japan, (4) Department of Public Health, Kitasato University School of Allied Health Sciences, Sagamihara, Japan, (5) Deparment of Preventive Medicine and Public Health, Iwate Medical University School of Medicine, Morioka, Japan, (6) Division of Microbiology, National Institute of Health Sciences, Tokyo, Japan |
| CYP1A lacalization in immune cells of rainbow trout exposed to benzo(a)pyreneSegnerHelmut1 |
Ayako Nakayama (1,4), Ivan Riesen (1), Elisabeth Eppler (2), Bernd Koellner (3), Kawai Shin'ichiro (4) |
(1) Centre for Fish and Wildlife Health, University of Berne, Switzerland, (2) Unversity of Zurich, Switzerland, (3) Friedrich-Loeffler Institute, Insel Riems, Germany, (4) Kobe College, Japan |
| Gene expression analysis of murine lungs following pulmonary exposure to diesel exhaust particles in the absence or presence of allergen. |
Rie Yanagisawa (1), Hirohisa Takano (1), Katsura Mizushima (2), Ken-ichiro Inoue (3), Kaori Sadakane (3), Toshikazu Yoshikawa (2) |
(1) National Institute for Environmental Studies, Tsukuba, Japan, (2) Kyoto Prefectural University of Medicine, Kyoto, Japan, (3) Oita University of Nursing and Health Sciences, Oita, Japan |
| Effect of perinatal exposure of maternal rats to brominated flame retardant HBCD on the developing immune system of the offspring |
Ryosuke Nakamura (1,2), Reiko Teshima (1), Akiko Hachisuka (1), Rika Nakamura (1), Jun-ichi Sawada (1), Makoto Shibutani (2) |
(1) Div. Biochem. Immunochem., Natl. Inst. Health Sci., Tokyo, Japan, (2) Lab. Verter. Pathol., TokyoUniv. Agr. Tech., Tokyo, Japan |
| Effects of in utero through lactational exposure of ethynylestradiol on immune system in F1 mice |
Hideki Miyaura, masahiro Takeyoshi |
ChemicalsAssessmentCenter, Chemicals Evaluation and Research Institute, Japan, Saitama, Japan |
| Immunization regimen for the evaluation of SRBC-specific IgG antibody response in a 14 days dosing period in rats |
Motoko Fukui, Suiji Shibata, Shigeru Hisada |
Safety Research Department, ASKA Pharmaceutical Co.,Ltd., Kanagawa, Japan |
| Production of anti-inflammatory cytokines, IL-10 and TGF-b1, in human polyclonal T cell line exposed to asbestos |
Megumi Maeda (1), Yoshie Miura (2), Yasumitsu Nishimura (1), Shuko Murakami (1), Hiroaki Hayashi (1), Takashi Nakano (3), Takemi Otsuki (1) |
(1) Department of Hygiene, Kawasaki Medical School, Kurashiki, Okayama, Japan, (2) Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, USA, (3) Department of Respiratory Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan |
| Effect of laughter on salivary endocrinological stress marker chromogranin A |
Masahiro Toda, Kanehisa Morimoto |
Department of Social and Environmental Medicine, OsakaUniversityGraduateSchool of Medicine, Osaka, Japan |
| Influence of solvents on skin sensitization assay of metals with LLNA method |
Tomoki Fukuyama, Hideo Ueda, Koichi Hayashi, Yukari Tajima, Atsuko Haishima, Hideaki Fujie, Yutaka Hayashi, Yasufumi Shutoh, Tadashi Kosaka, Takanori Harada |
The Institute of Environmental Toxicology Division |
| Synergistic effects of nanoparticles on respiratory pathological conditions |
Kenichiro Inoue (1), Hirohisa Takano (1,2), Rie Yanagisawa (1), Miho Sakurai (1), Takamichi Ichinose (3), Kaori Sadakane (3), Toshikazu Yoshikawa (2) |
(1) Environmental Health Sciences Division, National Institute for Environmental Studies, (2) Inflammation and Immunology, Kyoto Prefectural University of Medicine, (3) Department of Health Science, Oita University of Nursing and Health Science |
| Effects of indomethacin administered during late-gestation on the cytokine production in rat pups |
Kiyoshi Kushima, Keiko Oda, Shozo Sakuma, Michio Fujiwara |
Drug Safety Research Laboratories, Astellas Pharma, Osaka, Japan |
| An attempt to detect chemical allergic reactions using a mouse model |
Tomoki Fukuyama, Yukari Tajima, Hideo Ueda, Koichi Hayashi, Atsuko Haishima, Hideaki Fujie, Yutaka Hayashi, Yasufumi Shutoh, Tadashi Kosaka, Takanori Harada |
The Institute of Environmental Toxicology Division |
| Murine Food Allergy Model with Oral Sensitization and Oral Challenge (6) |
Tomoko Shindo (1), Nami Furuya (1), Yoshiyuki Tazura (1), KOhichi Kojima (1), reiko Teshima (2) |
(1) Hatano Research Institute, Food and Drug Safety Center, Kanagawa, Japan, (2) National Institute of Health Sciences, Tokyo, Japan |
| Changes in salivary physiological stress markers associated with winning and losing |
Masako Hasegawa, Masahiro Toda, Kanehisa Morimoto |
Department of Social and Environmental Medicine, OsakaUniversityGraduateSchool of Medicine, Osaka, Japan |
| Circadian rhythm of salivary chromogranin A and stress response in male university students |
Rei Den, Masahiro Toda, Kanehisa Morimoto |
The Department of Social and Environmental Medicine, OsakaUniversityGraduteSchool of Medicine, Osaka, Japan |
| The analysis for signal transduction in the human NK cell line exposed to asbestos and cytotoxicity of NK cells from patients with mesothelioma |
Yasumitsu Nishimura (1), Megumi Maeda (1), Shuko Murakami (1), Hiroaki Hayashi (1), Yoshie Miura (2), Kazuya Fukuoka (3), Takashi Nakano (3), Takemi Otsuki (1) |
(1) Dept. of Hygiene, Kawasaki Medical School, Kurashiki, Japan, (2) Eppley Institute for Cancer Research, Univ. of Nebraska Medical Center, Omaha, NE, USA, (3) Dept. of Respiratory Medicine, Hyogo College of Medicine, Nishinomiya, Japan |
| Influence of Restraint stress on immune system in mice |
Koichi Hayashi (1), Tadashi Kosaka (1), Tomoki Fukuyama (1), Yukari Tajima (1), Hideo Ueda (1), Satoru Yamaguchi (1), Makio Takeda (1), sayuri Kojima (1), Yasufumi Shutoh (1), Toshiaki Kitazawa (1), Shinichi Maki (1), Syuichiro Kimura (2), Takanori Harada (1) |
(1) The Institute of Environmental Toxicology,(2) Itoh Kanpo Pharmaceutical Co., Ltd |
| Analysis of cadmium-induced cytokine profiles by the antibody microarray of cytokines |
Motoyasu Ohsawa, Kazuko Takahashi |
Department of Health Sciences, Faculty of Pharmaceutical Sciences, TeikyoUniversity, Sagamihara, Japan |
| Enhancement of IgE-dependent allergic reactions in vivo and degranulation of mast cells in vitro by butylated hydroxytoluene （BHT） |
Kouya Yamaki, Shin Yoshino |
Department of Pharmacology, KobePharmaceuticalUniversity, Kobe, Japan |
| General Session (Poster Presentation) |
| Immunotoxicity evaluation of methotrexate in rats by intermittent dosing for two weeks |
Ryota Kawai, Tetsuo Aida, Shiho Ito, satomi Komatsu, Shinya Sehata, atsuko Muramatsu, Tadashi Furukawa, Sunao Manabe |
Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd. |
| Effects of airway exposure to diesel exhaust particles on atopic mice |
Kenichiro Inoue (1), Hirohisa Takano (1,4),Rie Yanagisawa (1), Takamichi Ichinose (2,) Akinori Shimada (3), Toshikazu Yoshikawa (4) |
(1) National Institute for Environmental Studies, (2) OitaUniversity of Nursing and Health Science, (3) University of Tottori, (4) Kyoto Prefectural University of Medicine |
| Cytokine productions of various cell types by nanomaterials in comparison with asbestos |
Kazuhiko Takahara (1), Takefumi Ikeda (1), Kohei Mizuno (2), Kunio Uchida (2), Kazuhiro Yamamoto (2), Hajime Kawasaki (2), Kayo Inaba (1) |
(1) Lab. of Immunobiol., Dep. of Animal Development and Physiol., Grad. Sch. of Biostudies, Kyoto University., (2) Advance Industrial Science and Technology |
| Effect of prenatal and postnatal exposure to low-level toluene and peptidoglycan on systemic Th1/Th2 immunity in infant mice |
Shoji Yamamoto, Atsushi Fukushima, Tin Tin Win Shwe, Rieko Hojo, Hidekazu Fujimaki |
ResearchCenter for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Japan |
| Effect of exposure to carbon black nanoparticles on the maturation and the accessory activity of mouse bone marrow-derived dendritic cells |
Eiko Koike(1), Hirohisa Takano (1), Ken-Ichiro Inoue (1), Rie Yanagisawa (1), Takahiro Kobayashi (2) |
(1) Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan, (2) Integrated Research Institute, Tokyo Institute of Technology, Yokohama, Japan |
| Effects of titanium dioxide (TiO2) nanoparticles on atopic dermatitis-like skin disorders |
Tomoko Kamachi (1,2), Hirohisa Takano (2,4), Rie Yanagisawa (2), Kenichiro Inoue (2), Eiko Koike (2), Takamichi Ichinose (3), Kaori Sadakane (3), Toshikazu Yoshikawa (4) |
(1) Graduate Shool of Environmental Sciences, University of Tsukuba, Tsukuba, Japan, (2) National Institute for Environmental Studies, Tsukuba, Japan, (3) Oita University of Nursing and Health Sciences, Oita, Japan, (4) Kyoto Prefectural University of Medicine, Kyoto, Japan |
| Gene expression analysis for hyperglycemia induced by glucocorticoids |
Takako Hamano, Toshinobu Shimizu, Naohisa Tsutsui |
Toxicology Laboratory, Mitsubishi Pharma Corporation, Chiba, Japan |
| Cross-talk between the nervous and immune systems through calcitonin gene-related peptide |
Kazutake Tsujikawa, Yusuke Ogitani, Ippei Otani, Emi Hirayama, Keiko Watanabe, Hiroshi Yamamoto |
Department of Immunology, GraduateSchool of Pharmaceutical Sciences, OsakaUniversity |
| Immixture of chronically activated T cells and surface Fas expression in peripheral CD4+25+ T cell fraction in silicosis patients.HAYASHI HIROAKI1, |
Hiroaki Hayashi (1), Yoshie Miura (2), Megumi Maeda (1), Shuko Murakami (1), Yasumitsu Nishimura (1), Masayasu Kusaka (3), Takemi Otsuki (1) |
(1) Department of Hygiene, Kawasaki Medical School, Kurasiki, Japan, (2) Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, U.S.A, (3) Kusaka Hospital, Bizen, Japan |
| Effects of exposure to electromagnetic fields on genotoxicity in rat astrocytes -application for immunotoxicity- |
Yuichi Miyakoshi, Hidesuke Shimizu, Hiroyuki Yanagisawa |
Department of public health and environmental medicine, The Jikei University school of medicine, Tokyo, Japan |
| The effect of plant oil on oral sensitization of food allergen, ovomucoid in mice |
Reiko Teshima, Haruyo Okunuki, Ryosuke Nakamura, Yuji Sato, Hiroshi Akiyama, Jun-Ichi Sawada |
National Institute of Health Sciences |
| Study for evaluation of phototoxicty by oral administration in BALB/c mice |
Shinji Utsunomiya, Yoshihiro Takahashi, Yasuhiro Tanaka, Kaori Kumano, Takahiro Nakamura, Hiroyuki Izumi, Hiroshi Tokado |
Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., Kagoshima, Japan |
| Analysis of Mechanism on Organotin-Induced Cell Death of T-Lymphocytesin an sight of the difference in its chemical structure |
Ken-Ichi Tomiyama, Takao Kuriyama, Akiko Yamaguchi, Yurie Sayama, Yoko Echizenya, Megumi Nakata, Nami Watanabe, Yasuaki Arakawa |
Department of Hygiene & Preventive Medicine, Faculty of Health Sciences, The University of Shizuoka, Shizuoka 422-8526, Japan |
| Induction of Interleukin-6 and metallothionein by metal compounds |
Seiichiro Himeno (1), Hitomi Fujishiro (1), Jiaming Yu (1), Kazuo Kobayashi (2), Tatsuya Hasegawa (3), Yoshiyuki Seko (3) |
(1) Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan, (2) Kissei Pharmaceutical Co., Ltd., Nagano, Japan, (3) Yamanashi Institute of Environmental Sciences, Yamanashi, Japan |
| Induction of autoimmune arthritis in mice induced by anti-type II collagen monoclonal antibodies |
Takayuki Saito, Kouya Yamaki, Shin Yoshino |
Department of Pharmacology, KobePharmaceuticalUniversity, Hyogo, Japan |
| Luncheon Seminar 1 |
| Applications for cell based assays in biopharmaceutical development - from batch release & stability to assessment of neutralising antibodies |
Wing Mark |
Huntingdon Life Sciences Ltd., Immunology and Cell Biology |
| Luncheon Seminar 2 |
| ImmunoToxicogenomics - Potential for the use of immunogenomics in preclincal toxicity assessment of pharmaceuticals |
Jacob Lawrence |
Charles River Laboratories Preclinical Services Edinburgh, Edinburgh, Scotland, UK |
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