The 10th Annual Meeting of JSIT 2003.9.25-26. Greenhall Sagamiono (Sagamihara) President: Hiroshi Hojo (Showa Pharmaceutical University) Special Lecture The interaction between genetic and environmental factors ; allergy as a model of common disorders ? Taro Shirakawa Department of Health Promotion and Human Behaviour , Kyoto University School of Public Health memorial Symposium Progress and problem of immunotoxicological research. −From analytical stage to Mechanism-based stage− Jun-ichi Sawada Division of Biochemistry and Immunochemistry, National Institute of Health Sciences Hiroshi Hojo Department of Hygienic Chemistry, Showa Pharmaceutical University Kenote Lecture Development and Future Perspective of Immunotoxicological Research … From the Analytical Stage to the Mechanism - based Stage Motoyasu Ohsawa Department of Toxicology and Environmental Health, Faculty of Pharmaceutical Science, Teikyo University, Sagamiko, Kanagawa, Japan Animal models for food allergy and the evaluation of allergenicity Reiko Teshima Division of Biochemistry and Immunology, National Institute of Health Sciences Toxicological Evaluation of Environmental Chemicals utilizing Animal model. Hidekazu Fujimaki. Environmental Health Sciences Division, National Institute for Environmental Studies Molecular toxicological approach for immunotoxicity evaluation in drug development … Introduction of toxicopanomics( toxicogenomics、toxicoproteomics, metabonomics) to immunotoxicological science … Ikuo Horii Worldwide Safety Sciences, Global Research ＆ Development, Pfizer Inc. Symposium <1> Chemical Sensitivity Fujio Kayama Center for Community Medicine, Division of Environmental Medicine, Jichi Medical School, Tochigi, Japan Kou Sakabe Environmental Health Center, The Kitasato Institute, Kitasato University, Tokyo, Japan Immunological effects by formaldehyde - Experimental evaluation by using mice - Takahiko Yoshida Department of Health Science, Asahikawa Medical College, Asahikawa, Japan Behavioural change in the pups produced by perinatal low concentration formaldehyde Hiroyuki Aikawa Department of Basic Clinical Science and Public Health, Tokai University School of Medicine, Knagawa, Japan The Role of " Neuro - Endoocrine - Immune " Axis in Chemical Sensitivity Kou Sakabe Environmental Health Center, The Kitasato Institute, Kitasato University, Tokyo, Japan Symposium <1> Toxicity assessment and side effect of biomedicine Organizer Shiro Ueda Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba university, Chiba, Japan Michihito Takahashi Showa University, School of Pharmaceutical Sciences Non - clinical experiments and clinical trials of new biologics in Japan Tamiko Suzuki - Nishimura The Organization for Pharmaceutical Safety and Research (OPSR) Complications of interferon therapy and their managemant Osamu Yokosuka Department of Medicine and Clinical Oncology Graduate School of Medicine, Chiba University, Chiba, Japan Efficacy and adverse reactions of anti -TNF - α monoclonal antibody in the treatment of rheumatoid arthritis Shiro Ueda Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba university, Chiba, Japan Workshop <1> International harmony of immunotoxicological evaluation method concerning medicine Organizer Kazuichi Nakamura Developmental Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan Guidance for Immunotoxicity Testing (Draft) and ICH. Jun-ichi Sawada Division of Biochemsitry and Immunochemistry, National Institute of Health Sciences, Tokyo, Japan ICH Immunotoxicology Survey Shigeru Hisada Safety & Pharmacokinetics Research Department, Teikoku Hormone Mfg., Co. Ltd. Workshop <2> Problems in the evaluation methods for antigenicity Organizer Eiji Maki Research & Development Division, Janssen Pharmaceutical K. K. The controversial point of antigenicity test in development of medicines Eiji Maki Research & Development Division, Janssen Pharmaceutical K. K. Usefulness of Mouse Popliteal Lymph Node Assay as an Allergenicity Test. T Aida, T Kimura Medicinal Safety Research Laboratories, Sankyo Co., Ltd General Oral Presentation Role of GSH in Arsenicals - Induced Immnotoxicity Teruaki Sakurai, Kitao Fujiwara. Laboratory of Environmental Chemistry, School of Life Science, Tokyo University of Pharmacy and Life Science Effect of inorganic arsenic exposure from the before mating on the immune system of mouse offspring. T. Itoh (1) T. Yoshida Y, Nakagi (1), K Nakai (2), C. Watanabe (3), H. Yamauchi (4) H. Satoh(2) Asahikawa Medical College, (2)　Tohoku University, (3)　University of Tokyo, (4) St. Marianna University Metal - induced histomorphological injury and the alterations in the amounts and proportion of unsaturated disaccharides of glycosaminoglycan derived from proteoglycan. Yasuaki Arakawa (1), Kanako Nishimura (1), Toshio Imanari (2) (1)Department of Hygiene & Preventive Medicine, Faculty of Health Science, The University of Shizuoka, (2) Department of Analytical Chemistry, Faculty of Pharmaceutical Science, The University of Chiba. Beneficial effects of a milk drink fermented by lactic acid bacteria on NK cell activity in healthy human subjectｓ with smoking habit M , Nanno . (1), Y, Matshuoka(2), T, Takeshita(2). , K , Morimoto (2) (1)Yakult Central Institute for Microbiological Research, (2)Osaka University Graduate School of Medicine Faculty of Medicine (+)-Catechin protects against myelotoxicity in mice treated with 5-fluorouracil. Fumihide Takano (1), Tomoaki Tanaka (2), Jiro Aoi (2), Nobuo Yahagi (2), Shinji Fushiya (2) (1) Departmennt of Chemistry and Pharmacognosy, Faculty of Pharmaceutical Science, Kanazawa University, (2) Experimental Station for Medicinal Plant Studies, Graduate School of Pharmaceutical Effects of a Statin, simvastatin, on human myeloma cells T Otsuki , H Sakaguchi, T Hatayama , A Takata , F Hyodoh Dept . Hyg ., Kawasaki Med . Sch . Kurashiki, Japan Murine Food Allergy Model with Oral Sensitization and Oral Challenge (1) Yukiko Kanazawa (1), Tomoko Shindo (1), Yoshiaki Saito (1), Kenji Usumi (1), Kohichi Kojima (1), Reiko Teshima (2) (1) Hatano Reseach Institute, Food and Drug Safety Center, Kanagawa,Japan, (2) Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, Tokyo, Japan Murine Food Allergy Model with Oral Sensitization and Oral Challenge (2) - Observation of Small Intestine as a Specific Parameter - Tomoko Shindo (1), Yukiko Kanazawa (1), Yoshiaki Saito (1), Kenji Usumi (1), Kohichi Kojima (1), Reiko Teshima (2) (1) Hatano　Research Institute, Food and Drug Safety Center , Kanagawa, Japan, (2) Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, Tokyo Japan Effect of the phosphodiesterase �W inhibitor rolipram on Th 1/Th 2 immune responses Kouya Yamaki, Xiaojuan Li, Shin Yoshino Department of Pharmacology, Kobe Pharmaceutical University Effects of chlorinated organic solvent on type I allergic reaction Makoto Seo, Koji Ikeda, Takeo Yamagiwa, Tadayoshi Ikemoto, Masahiko Sato and Hisamitsu Nagase Laboratory of Hygienics, Gifu Pharmaceutical University, Gifu, Japan Identification of tissues producing IL-6 in rats treated i. p. with carbon tetrachloride Kenzaburo Yamadi (1), Miho Aoki (1), Ryoji Zuinen (1), Junko Ito (1.2), Mitsune Yamaguchi (1), Toshiyuki Chikuma (1), Hiroshi Hojo (1) (1) Department of Hygienic Chemistry, Showa Pharmaceutical University., (2)Laboratory of Biochemisry, Sagami Women's University Immunotoxicity of di-2-ethylhexylphthalate (DEHP) in rodents S. Ohara (1.2), K . Ueno (1) and T . Takezawa (2) (1)Geriatric Pharmacology and Therapeutics, Graguate School of Pharmaceutical Sciences, Chiba University, (2)Laboratory of Animal Cell Biology, National Institute of Agrobiological Sciences 17 β-Estradiol enhances mouse contact sensitivity Humitoshi Sakazaki, Kazunori Fujii, Yasunori Ishikawa, Sayaka Kodama, Hitoshi Ueno and Katsuhiko Nakamuro Department of environmental health, Faculty of Pharmaceutical Sciences, Setsunan University Sensitizer in conformity with globally harmonized system of classification and labelling of chemicals (provisional list) K. Sato, Y. Kusaka Department of Enviromental Health, School of Medicine, Fukui Medical University General Poster Presentation Effect of dialkyl phthalates on the activation of mast cells Ryosuke Nakamura, Haruyo Okunuki, Yoshiro Saito, Reiko Teshima, Jun-ichi Sawada Division of Biochemistry and Immunochemistry, National Institute of Health Sciences. Evaluation of the effectiveness of rat peripheral lymphocytes phenotyping Satoko Kakiuchi, Hideshi Kaneko, Kimiko Jonouchi, Sachiko Ohara, Natsuki Kitaima, Yoshimi Sato, Azusa Tamura, Daishiro Miura, Yoshinori Kasahara Safety research department, Pharmaceuticals development research laboratories, Teijin Limited The influence of mental stress on serum albumin in mouse Nobuhiro Goi et al University of Shizuoka, Aichi Medical University and Osaka Pref. Institute of Public Health Historical date of anti - SRBC antibody titers in wistar rats Koichi Hayashi, Tadashi Kosaka, Yukiko Takeuchi, Sayaka Ishimine, Tsutomu Matsumoto, Hideaki Fujie, Yasufumi Shutoh and Takanori Harada Institute of environmental toxicology The apoptosis induced by tributyltin (TBT) chloride in murine macrophage cells in vitro Masashi Tsunoda (1), Ken Nakano (2), Nobuhiro Konno (3) (1)Department of Pubulic Health, School of Medicine, Fukushima Medical University, (2)Fukushima Institute of Public Health, (3)Koriyama Women's University & College Differential effects of resveratrol on apoptosis of spleniclymphocytes Jianhong ZHAO(1)(2)，Yukitomo Arao(1)(2)，Kazuhiro Ikeda(1)(2)，Atsumi Kikuchi(1)(2)，Fujio Kayama(1)(2) (1) Division of Environmental Immunology and Toxicology, Department of Health Science , Jichi Medical School, (2)CREST, Japan Science and Technology Corporation Degradation of glyceraldehyde-3-phosphate dehydrogenase induced by 4-hydroxy-2-nonenal and acrylonitrile, and distribution of its degradation enzyme in mononuclear cells Yukihiro Tsuｃhiya, Mitsune Yamaguchi, Kayoko Hishinuma,Atsushi Shimada, Toshiyuki Chikuma, Hiroshi Hojo Department of Hygienic Chemistry, Showa Pharmaceutical University Respiratory sensitization studies of 2 agricultural chemicals by using a challenge phase-added mouse IgE test Hideo Ueda, Tadashi Kosaka, Koichi Hayashi, Koichi Ebino, Shoji Teramoto Institute of Environmental Toxicology Analysis of responsible factors for changes in tissue concentration of zinc Masao Sato (1), Minoru Higashimoto (1), Miwa Yanaga (1), Masafumi Takiguchi (1), Masuo Kondoh (2), Shinya Suzuki (1) (1)Tokushima Bunri University, Faculty of Pharmaceutical Sciences, (2)Syowa Pharmaceutical University Alteration of type 1 and type 2 cytokine levels in the peripheral blood during the juvenile period F. Otsuka (1), S. Sasamoto (1), K. Takahashi (1), T. Yoshida (2) and M. Ohsawa (1) (1)Dept. Toxicol. Environ. Health, Fac. Pharmaceutical Sci. , Teikyo University,　(2)Department of Hygiene, Asahikawa Medical College Effects of low doses of dioxin on immune response K. Inouye (1,2), X. Pan (1,3), N. Imai (4), C. Tohyama (1,3), and K. Nohara (1,3) (1)Environmental Health Sciences Division, National Institute for Environmetal Studies; (2)Domestic Research Fellow, JSPS; (3)CREST, JST; (4)Safety research Group 3, Shin Nippon Biomedical Laboratories, Ltd. Growth inhibition in Jurkat T cells having a constitutively active aryl hydrocarbon receptor T. Ito (1,2), S. Tsukumo (1,2), M. Yamamoto (2,3), H. Motohashi (3), N. Suzuki (3), Y. Fujii - Kuriyama (2,3), J. Mimura (3), C. Tohyama (1,2), K. Nohara (1,2) (1)National Institute for Environmental Studies, (2)CREST, JST, (3)TARA Center, University of Tsukuba. Inhibitory effect of feeding β-carotene on type�Tallergy in mice Y. Sato(1) , H. Akiyama(1), T.Watanabe, (1), M.H. Nagaoka(1), H. Suganuma(2), T. Inakuma(2), T. Maitani(1)　 (1)National Institute of Health Sciences, (2)Research Institute, Kagome Co. Ltd Development of a modified local lymph node assay with non - radio isotopic endpoint and application to risk assessment of chemicals Yamashita K. , Idehara K. Daicel Chemical Industries, LTD.